Blood Systems Research Institute UCSF, San Francisco, CA, 94118, USA Brian Custer & Shannon Kelly University of Illinois at Chicago, Chicago, IL, 60607, USA Dawood Darbar Mayo Clinic, Rochester, MN, 55905, USA Mariza de Andrade Vanderbilt University, Nashville, TN, 37235, USA Michael DeBaun,...
291 metabolite peaks in 2466 participants from the Jackson Heart Study (JHS), a Black epidemiological cohort in Jackson, Mississippi, and validated findings in the Multi-Ethnic Study of Atherosclerosis (MESA;n = 995) and Health, Risk Factors, Exercise Training and...
Polygenic scores were generated within the HUNT cohort, the training set18. Lipid values were extracted from the electronic health record; absence of lipid-lowering therapy was prioritized. For each trait, the model with the best fit, as measured byR2, was chosen to apply to the testing set,...
Polygenic scores were generated within the HUNT cohort, the training set18. Lipid values were extracted from the electronic health record; absence of lipid-lowering therapy was prioritized. For each trait, the model with the best fit, as measured byR2, was chosen to apply...
(5.38) years for Cardiovascular Health Study (CHS). The Amish cohort had a higher-than-average concentration of LDL-C (140 [SD 43] mg/dL) and HDL-C (56 [SD 16] mg/dL) as well as lower TG (median 63 [IQR 50] mg/dL) consistent with the known founder mutations inAPOBandAPOC37...
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Mariza de Andrade Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA Xiuqing Guo Bloodworks Northwest, ...
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses from fifteen co
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Mariza de Andrade Department of Family Medicine, University of California San Diego, La Jolla, CA, USA Matthew A. Allison Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingha...
Polygenic scores were generated within the HUNT cohort, the training set18. Lipid values were extracted from the electronic health record; absence of lipid-lowering therapy was prioritized. For each trait, the model with the best fit, as measured byR2, was chosen to apply to the testing set,...