whole genome sequencinggenome maintenanceBreast cancer was the first to take advantage of targeted therapy using endocrine therapy, and for up to 20% of all breast cancer patients a further significant improvement has been obtained by HER2‐targeted therapy. Greater insight in precision medicine is ...
Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Swede...
Since this association might have major consequences for human health, we evaluated 51 whole genomes of breast cancer samples for the presence of BLV DNA. Among 32 billion sequencing reads retrieved from the NCBI database of genotype and phenotype, none mapped on different strains of the BLV ...
Whole genome sequencing (WGS) with paired germline tissue can be used to reconstruct the evolutionary “life history” of breast tumors, providing a detailed roadmap for early or late clonal and subclonal genomic events that help prioritize therapeutic targets12,13,14. To date, however, the evol...
Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond confirming recurrent mutations in genes previ...
Nik-Zainal, S., et al., Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature, 2016. 534(7605): p. 47-54.研究人员测了560位乳腺癌患者(556位女性和4位男性)的肿瘤和正常组织的全基因组,共鉴定出93个驱动基因,以及与缺陷DNA修复和BRCA1及BRCA2功能相关的突变标签(...
Because cases of Triple-Negative Breast Cancer (TNBC) are so genetically different, whole-genome sequencing is needed to detect the subtle molecular differences that might point to specific treatments for individual patients. Dr. John Carpten, Ph.D., head of the IntegratedCancerGenomics Division at...
Breast cancer (BC) is a prevalent cancer of the female reproductive system and a major contributor to cancer-related mortality. The activation of NLRP3, a key inflammasome, has been extensively associated with tumor-related molecular and cellular processes; however, the regulatory mechanisms and spec...
To test the performance of a new sequencing platform, develop an updated somatic calling pipeline and establish a reference for future benchmarking experiments, we performed whole-genome sequencing of 3 common cancer cell lines (COLO-829, HCC-1143 and HC
of Whole-genome bisulfite sequencing of cell-free DNA identifies signature associated with metastatic breast cancer C Legendre,G Gooden,K Johnson,... 被引量: 38发表: 2015年 Whole-genome bisulfite sequencing of cell-free DNA identifies signature associated with metastatic breast cancer. et al. ...