根据2021年世界卫生组织中枢神经系统肿瘤分类(WHO CNS5),准确检测分子变异,如单碱基替换(IDH1/2,TERT)、染色体变异(CDKN2A、1p/19q缺失和EGFR扩增)或启动子甲基化(MGMT),对于脑胶质瘤患者的管理至关重要。本研究的目的是在WHO CNS5背景下,评估检测IDH1/2状态的新方法。 使用NGS对34例胶质瘤样本同时进行了多个生...
WHO CNS5 requires assessment of multiple mutations for glioma classification.We demonstrated that qPCR or NGS performed in reference genetic laboratories, rather than IHC, is the most reliable method for IDH1/2 analysis. Clinicians should be aware of discrepancies in MLPA or IHC results and seek ...
1. The 2021 WHO Classification of Tumors of the Central Nervous System:clinial implications. Neuro-oncology. 2021. 2.Pediatric low-grade gliomas: next biologically driven steps. Neuro Oncol. 2018. 3.Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with ...
引入儿科型弥漫性低级别胶质瘤的类别是为了区分由丝裂原活化蛋白激酶(MAPK)通路活化驱动的肿瘤和通常由IDH驱动的成人型低级别胶质瘤(The category of paediatric-type diffuse low-grade glioma was introduced to distinguish tumours driven by an activation in the mitogen-activated protein kinase (MAPK) pathway f...
Śledzińska P, Bebyn M, Szczerba E, Furtak J, Harat M, Olszewska N, Kamińska K, Kowalewski J, Lewandowska MA. Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics. Mol Diagn Ther. 2022 Sep 2. doi: 10.1007/s40291-022-00612-3. Epub ahead of print...
2021年 9月第 21卷 利益冲突 无 参考文献 【1】yang xj. from the neurosurgeons' angle to interpret thedevelopment of histological classification of central nervoussystem tumor[j]. zhongguo xian dai shen jing ji bing za zhi , 2008 , 8 : 376 - 383.[杨学军.从神经外科医师角度解读中枢神经系统...
【摘要】 2021年世界卫生组织中枢神经系统肿瘤分类(第五版,简称新版肿瘤分类)在组织学诊断的基础上引入一系列分子诊断指标,形成整合诊断及分层报告体系,并新定义多种肿瘤类型和亚型,反映出目前神经肿瘤相关领域对此类疾病遗传背景和临床特征的理解。本文综述新版肿瘤分类关键的分子诊断指标及相应检测方法,旨在为临床认识疾病...
。2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist》(doi: 10.1007/s00234-022-03008-6.)。 世界卫生组织(WHO)于2021年发布的第5版《中枢神经系统肿瘤分类》(WHO CNS5)以2016版...
《Neuroradiology》杂志2022 年7月22日在线发表英国伦敦Great Ormond Street Hospital for Children NHS Foundation Trust的Cillian McNamara , Kshitij Mankad , Stefanie Thust, 等撰写的综述《2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist》(doi: 10.1007/s002...
Interpretation on the diagnostic molecular parameters in the 2021 WHO Classification of Tumors of the Central Nervous System (fifth edition) LIU Xing,CHEN Hui-yuan,ZOU Wan-jing,LI Gui-lin 【Abstract】 The 2021 WHO Classification of Tumors of ...