These proteins are key determinants of intracellular drug concentrations, as they actively regulate the traffic of small molecules across the cell membrane. Thus, a cell may be “resistant” to a drug because not much of this drug remains inside it for a significant effect to be achieved. The...
the kinase, their phosphorylation decreasesand microtubules are stabilized around kinetochores (Figure2). In line with this, Aurora-B kinase activity does notrequire any modulation and can remain maximal duringmitosis but, its localization is essential for its correct func-tion. Our study of CPC by...