(STUD); (3) circulatory (ischemic heart disease, heart failure, hypertension, stroke); (4) respiratory (asthma, chronic obstructive pulmonary disorder); (5) inflammatory or musculoskeletal (osteoarthritis, osteoporosis, rheumatoid arthritis); (6) diabetes; (7) kidney disease (chronic kidney disease...
Dear Editor,Crohn's disease (CD) is a chronic inflammatory disease that may affect any segment of the gastrointestinal tract. Extra-intestinal manifestations of CD, including articular, oral, ocular, and cutaneous symptoms, affect up to ... A Kajita,Y Kawakami,S Hiraoka,... - 《Journal of ...
Vertex scientists and our collaborators are working on new medicines to cure or significantly advance the treatment of hepatitis C, cystic fibrosis, rheumatoid arthritis, epilepsy and other life-threatening diseases. Founded more than 20 years ago inCambridge, MA, we now have ongoing worldwide resear...
she had experienced a breakthrough case. “I didn’t die, and I wasn’t gonna die, but that does not take away from how miserable it was. It was terrible. I still have side effects. I was sick for two months almost,”she explainedto the shock jock. “I...
Yamaguchi, N. et al. Smoking status and self-reported race affect the frequency of clinically relevant oncogenic alterations in non-small-cell lung cancers at a United States-based academic medical practice.Lung Cancer82, 31–37 (2013).
which are known to affect bone microarchitecture [128]. All studies showed that TBS was significantly associated with fracture, independent of BMD. In two studies of postmenopausal women with rheumatoid arthritis, TBS but not BMD was associated with a prevalent radiographic vertebral fracture [118,119...
In a new study by the Potsdam Institute for Climate Impact Research (PIK), researchers analyzed how erratic weather events, increasingly intensified by global warming, affect global production and consumption across different income groups. The results confirm previous studies that the poorest people wor...
Conclusions: In patients with rheumatoid arthritis who hope to conceive, continuing biologic disease-modifying anti-rheumatic drugs at the time of conception could shorten the time to pregnancy. Using biologic disease-modifying anti-rheumatic drugs before pregnancy does not affec...
In cancer treatments this is exploited to achieve higher cell death of tumour cells, this inhibition would affect adversely the viability of brain cells in an ageing context thus enhancing neurodegeneration. The nucleus - cytoplasm bidirectional exchange of molecules occurs through the nuclear pore ...
New data have provided important insights into the molecular and genomic characteristics of LCINS, which are distinct from those of smoking-associated lung cancers and directly affect treatment decisions and outcomes. Herein, we review the emerging data regarding the aetiology and features of LCINS, ...