MPN)、骨髓增生异常性/骨髓增殖性肿瘤(myelodysplastic/ myeloproliferative neoplasms,MDS/MPN)诊断及分类,强调了特定遗传学改变在疾病分型中的作用,去除了既往诊断分型中模糊和预后意义不显著的类型,如“慢性髓性白血病加速期(chronic myelo...
本研究以骨髓增生异常综合征(myelodysplastic syndrome/neoplasms,MDS)和急性髓细胞白血病(acute myeloid leukemia,AML)为例,重点介绍这两种重要的髓系肿瘤的诊断要点、重要概念,以及它们在WHO-HAEM5 和ICC分类发生的主要变化和不同,以便我们更...
Myeloid neoplasms that arise secondary to exposure to cytotoxic therapy or germline predisposition are grouped in this category. AML transformation of MPN is retained in the MPN category, while AML transformation of MDS and MDS/MPN is kept under AML-MR (see above). The framework of this disease...
[1]Patel, Nisha, and Katherine R Calvo. “How I diagnose myeloid neoplasms with germline predisposition.” American journal of clinical pathology vol. 160,4 (2023): 352-364. doi:10.1093/ajcp/aqad075 [2]叶向军,唐海飞,卢兴国,等.《第5版WHO造血淋巴肿瘤分类:髓系和组织细胞/树突细胞肿瘤》解读[...
“How I diagnose myeloid neoplasms with germline predisposition.” American journal of clinical pathology vol. 160,4 (2023): 352-364. doi:10.1093/ajcp/aqad075 [2]叶向军,唐海飞,卢兴国,等.《第5版WHO造血淋巴肿瘤分类:髓系和组织细胞/树突细胞肿瘤》解读[J].临床检验杂志, 2022(007):040. [3]...
ICC-2022 versus WHO-2022 classification systems for acute leukemias and myeloid neoplasms: The perspective from two classical morphologistsdoi:10.1002/ajh.26963Zini, GinaBennett, John M.American Journal of Hematology
Classifification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia(2022) 36:1703-1719.https://doi.org/10.1038/s41375-022-01613-1.（2）The 5th edition of the World Health Organization Classifification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia(2022) 36:...
Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 2022;36(7):1703-1719. doi:10.1038/s41375-022-01613-1 ...
The WHO classification of the myeloid neoplasms is outlined in Tables 1to 7. The detailed criteria for each subtype can be found in the WHO monograph.1 Table 1. WHO classification of acute myeloid leukemia Acute myeloid leukemia with recurrent genetic abnormalities Acute myeloid leukemia with t(8...
For myeloid neoplasms in particular, the introduction of the WHO-HAEM5 classification system in 2022 represents a turning point in the field of hematologic oncology. In contrast to its predecessors, this system takes a genetic-centric approach that recognizes the paramount importance of genetic alterat...