White matter (WM) diseases are characterized by progressive degeneration of axons, oligodendrocytes and myelin sheath in one specific or multiple regions of the central nervous system (CNS). From: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021 ...
In primary adipocytes, we found that FGF21 stimulates CCL11 production through the KLB-ERK1/2 signaling cascade. Consistently, ERK1/2 has been shown to mediate both IL-17A- and IL-9-induced CCL11 expression by phosphorylating the transcription factor STAT3 to transactivate the Ccl11 gene promot...
T cell receptor and major histocompatibility complex. The innate immune response of shrimp has been shown to be triggered almost instantaneously in response to peptidoglycan stimulation [15] and is believed to be the primary defence mechanism against infection in this...
New Hampshire conducts a partially “open” primary, which allows voters who register as independent to participate in either of the two parties’ ballots. Anexit poll from CNNsuggested that of the independents who voted in the Republican primary, the split was 58-39 in favour of Haley. ...
p>Some descriptive epidemiologic characteristics of primary bone cancers were presented for black and white residents of New York State (1975鈥 1980) using data from the population-based New York State Cancer Registry. Average annual race- and age-specific incidence rates were calculated for ...
Indeed, let us take the Aristotelian definition of the noun, that is of the chief element of metaphor. The noun is the primary semantic unit. It is the smallest significant element. It is a composite phond semantikd whose elements are themselves without significance (asemos). The noun ...
[11], and the mechanism is complicated in mammals, which rely on primary cilia. Hh signaling is mainly regulated by the cell membrane receptors Patched (Ptc) and Smoothened (Smo). The nuclear transcription factor (glioma-related gene, Gli) family includes many multifunctional transcription factors...
Within the food chain, the power of large corporations, especially retailers and fast food companies has increased, while that of the primary producers – the farmers – has diminished, particu- larly in developing countries. In the current indus- trial food system, there is significant market ...
We also need to rethink our definition of neighbor. If we accord the honor and care of “neighbor” only to those who look like us, think like us, and act like us, then we are doomed to always live in the land of “us and them.” Can we instead dare to find common ground and ...
The innate immune response of shrimp has been shown to be triggered almost instantaneously in response to peptidoglycan stimulation [15] and is believed to be the primary defence mechanism against infection in this group of species. A number of potential antimicrobial peptide coding genes have been ...