Remarkably, the cellular and molecular mechanisms that underpin white matter invasion remain almost entirely unknown. Here, we investigated the impact of the white matter microenvironment on tumour cell fate by
Multiple sclerosis (MS) is a chronic inflammatory disease in which demyelinated lesions are present both in the grey (GM) and white matter (WM) of the central nervous system. MS presents as a relapsing remitting (RRMS) or progressive disease course. Demyelinated axons can be remyelinated ...
The distribution of grey and white matter changes was evaluated and overall as well as regional severity was graded. Total glial numbers in frontal white matter were counted using a light microscope. Oligodendrocyte and astrocyte quantities as well as astrocytic reactivity were assessed from frontal ...
Why does white matter appear different from gray matter? What is the difference between white matter and grey matter? What is the difference between "white matter" and "gray matter"? Explain the difference between grey and white matter. Are their functions different?
Molecular Neurodegeneration (2023) 18:24 https://doi.org/10.1186/s13024-023-00616-5 Molecular Neurodegeneration RESEARCH ARTICLE Open Access NF‑κB is a critical mediator of post‑mitotic senescence in oligodendrocytes and subsequent white matter loss Judith Stefanie Schlett1†, ...
We combined DTI, immunohistochemistry and mRNA expression analysis and examined the effects of somatosensory experience in adult rats. First, we observed experience-induced DTI differences in WM and in grey matter structure. C-Fos mRNA expression, a marker of cortical activity, in the barrel cortex...
47 The aquaporin 4 positive cell showed vacuole-shape under microscope, mainly at edema and cortex around trauma, near vessel, astrocyte, choroids plexus and ependyma ofwhite matter, etc. 48 Objective To observe the expression of GDNF protein and apoptosis of neuroglial cells in the neonatal ...
Inflammation and immunological alterations, such as T-cell and cytokine changes, are implicated in bipolar disorder (BD), with some evidence linking them to brain structural changes (e.g., cortical thickness (CT), gray matter (GM) volume and white matter (WM) microstructure). However, the con...
The condition is histopathologically defined by focal lesions with patchy areas of increased oligodendroglial cell density at the grey-white matter boundary and heterotopic neurons in the white matter. Approximately half of the individuals with MOGHE carry brain somatic variants in the SLC35A2 gene,...
conditions [23,25,26]. Age-related decline in regeneration hinders myelin debris clearance, causing inflammation and impaired remyelination, which can be restored by stimulating cholesterol transport [27]. In the aging rodent brain single-cell RNA sequencing from white and/or grey matter revealed...