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Results are reported either as percentage of CD137+ of CD8+ cells (labeled as CD137+/CD8+ cells) or percentage of CD137+ events among TCR-transduced CD8+ T cells (only for TCR-transduced patient T cells in Extended Data Fig. 8). In some experiments, cells were labeled with 0.75...
Complete loss of function of either JAK1 or JAK2 is lethal in mice and has not been described in humans[32,33]. However, activating mutations of JAKs are found in association with malignant transformations, the most common being the gain-of-function V617F mutation of JAK2 in polycythemia ...
Mutations in the cysteine string of DNAJC5 have been associated withHuntington’s disease. [artwork credit] *Interpreting 23andMe data here can be confusing because 23andMe lists an A or T as possible alleles but one isn’t always sure which strand the research literature refers to and if tha...
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Liquid biopsies are already used to guide treatment of people with confirmed cancer. They help monitor the spread of cancer to other parts of the body; identify a tumor's genetic changes, or mutations; determine what drug treatments might work best for specific patients; and reveal whether treat...
It's harder to keep a cyberpunk character alive inCY_BORGthan in certain other cyberpunk RPGs; even if they do survive and level up, they'll likely be riddled with unattractive nano-mutations, burdened with debts, dying from a terminal condition like theprotagonist ofCyberpunk 2077, or on...
Data are presented as relative PrestoBlue signal to control. Error bars represent SEM of three independent experiments. (B) CI values of ovarian cancer cell lines with selected mutations. Black indicates mutation; gray no mutation. Cell lines were divided into synergistic (CI < 0.5) and non...
Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research ...