A cancerous tumor is malignant, meaning it can grow and spread to other parts of the body.What is it called when cells begin to divide uncontrollably?Sometimes the cells in part of a multicellular organism divide uncontrollably. The result is a large mass of cells called a tumour . If ...
CEA, a tumor-associated antigen expressed on the surface of cancer cells originated from endoderm, is a structural protein of cell membrane. In CRC, CEA-positive rate is no less than 90% [28]. CEA has been recognized as an independent prognostic factor for CRC, associated with recurrence [2...
Recent studies show substantial growth-promoting properties of nicotine (NIC) in cancer, which is a combined outcome of genetic and epigenetic alterations. However, the role of epigenetic modifiers in response to NIC in breast cancer is less studied. In
The Class I HLA molecules of these cancerous cells present peptides from this protein, including VYGFVRACL. This peptide is presented in the context of HLA-A24 (Arai et al., (2001) Blood 97 (9): 2903-2907, and Tajima et al., Int. J. Cancer (2004) 110: 403-412). Therefore, ...
"It has become increasingly clear that one of the key determinants of disease progression is the ability of the tumour cell to change the micro-environment they exist in. We want to know how. "People tend to think of cancer as a foreign invader, but … Read the full-text article, tr...
These complexes exhibited specific cytostatic effects on cancerous cells, but not on normal, non-transformed cells. The key molecular feature responsible for inducing cytostasis was the lack of polarity in the complexes, attributable to large, apolar benzoyl protective groups on the hydroxyl groups ...
Interestingly, recent data indicate that SA may be useful in cancer treatment in a form other than the dietary intervention. A sialic acid-SA conjugate nanocomplexes with encapsulated ibrutinib, which is an inhibitor of Bruton’s tyrosine kinase, effectively targeted tumour-associated macrophages both...