This solution readily cleaves any bonds conjugating the cation channel protein to the resin, so that the protein can removed from the resin, and collected for further analysis to determine whether the potential drug or agent is bound to the protein. After the cation channel protein has been ...
In the presence of vardenafil, the GαT∗–PDE6 complex forms at a 2:1 stoichiometric ratio and does not readily form in its absence. The GαT∗ subunit is indicated by the red arrows. B, the improved cryo-EM structure of the PDE6 heterotetramer. The PDE6α (cyan), PDE6β (...
Burrowing through soils and sediments, a problem readily solved by evolution, presents a substantial obstacle for biomimetic robots attempting burrowing locomotion. In all instances of movement, the thrust in the forward direction must be superior to the resisting forces. The forces acting during burrow...