Structural systems biology Phenotypic differences are correlated to distinctions in GBA gene variations, as evidenced by genotype-phenotype research. One can categorize Gaucher disease variants, present in the biallelic state, as either mild or severe, predicated on the form of Gaucher disease they are...
We determined accelerated aging for a participant by their predicted age surpassing their actual age, and we highlighted genetic and environmental influences linked to this novel phenotype. A genome-wide association study of accelerated aging phenotypes revealed a heritability estimate (h^2 = 12309%)...
Biogenic amines are important sensory organ modulators in insects16. Our results also support this for the malaria mosquito ear as several biogenic amine receptors were expressed in both sexes (Fig.1c, d). An ortholog of the octopamine β2 receptor inDrosophila,AGAP002886, was the highest expre...
Upregulation of various forms of cancer, including kidney cancer, has been documented. Approximately 3% of all cancers diagnosed worldwide are kidney cancers, manifesting nearly twice as frequently in men compared to women. To disrupt the function of the target gene, this study was undertaken. ...
falciparum growth in erythrocytes by fusidic acid does not exhibit the classic ‘delayed death’ phenotype observed for apicoplast-targeted proteins. Indeed, the inhibition of the parasite occurred both in the first as well as the second cycle of infection of P. falciparum parasites in blood ...
Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN Nat. Biotechnol., 28 (2010), pp. 271-274 CrossrefView in ScopusGoogle Scholar 4 C.F. Valori, K. Ning, M. Wyles, R.J. Mead, A.J. Grierson, P.J. Shaw, M. Azzouz Systemic Deliver...
Anatomical location of the appendix was determined during autopsy. Appendix length was measured in millimeters with a ruler and completeness of mesoappendix was determined by one of the authors. Sex of the bodies was determined based on the observed phenotype, and their age was recorded based on ...
From our data, we ascertain the fundamental principle that this integrated methodology is effective in discovering novel candidate GD genes, showcasing that loss-of-function alterations in NLGN3 can contribute to the pathogenesis of GD. The newly discovered link between genotype and phenotype indicates...
Indeed, the PCR analysis has indicated that all the single clones and the pools selected by FACS have the CAT gene inserted in the genome. To identify the gene involved in the phenotype of clone 296-C2H, the genomic DNA was digested with restriction enzymes individually, which allow us to ...
Production of proteins comprising the GD domain is inhibited by antisense polynucleotides according to the invention, and such antisense polynucleotides may inhibit apoptosis, senescence and the like, and/or reverse the transformed phenotype of cells. A heterologous expression cassette maybe used to ...