The DNA nucleotide is made up of four base pairs, which are guanine, thymine, cytosine, and adenine. The four strands are represented by letters (G-C, A-T). The bases pairs are the ones that determine the gene sizes within the DNA molecules. Answer ...
As for this invention was substituted - the pyrimidine ring which replaces those relative ones and the benzene which possess pyridine sounds and - benzo thiazole (benzokisazoru) it regards. And, as for that so the PDE4 inhibiter which is, in the medical supply composition which consists of ...
EP0201188 1986-12-17 5-Substituted pyrazolo[4,3-d] pyrimidine-7-ones, process for preparing the compounds and pharmaceutical compositions comprising the compounds. EP0352960 1990-01-31 Purine compounds, process for their preparation and pharmaceutical compositions. EP0371731 1990-06-06 Quinazolinone ...
If m, n, and p are 2 or greater, respectively adjacent ones of the plurality of R1 to R3 [groups] may be linked to each other to form a cyclic structure. M and Q are each independently a carbon atom or a nitrogen atom. q represents an integer from 0 to 3 and is preferably an ...
Additionally, acridinones blocked the transmission to mosquitoes by preventing oocysts development [72]. The haloalkoxyacridinones are a new class of acridinone [83]. Some of them exhibit extraordinarily strong anti-malarial activity in vitro, with favourable IC50 values of 1 μM [84]. ...
(Novartis) and the triazolopyrimidine DSM265 (Takeda) (www.mmv.org/research-development/mmv-supported-projects). Interestingly, from all the pipeline opportunities, there are very few target-based programs, the DHODH inhibitors DSM265 and DSM411 being the most advanced assets in clinical development...
SPIROCYCLIC-6,7-DIHYDRO-5H-PYRAZOLO 1,2-A|PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINESThe present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, ... LM John,CM Phillip,DJ Far-Jine,... 被引量: 0发表: ...
This invention relates to the manufacture of new pyridoacridine derivatives which are useful as chemotherapeutic agents. They are distinguished by their parasiticidal action, particularly against malaria parasites. We have now found that new parasiticides, namely 1:2:3' :2'-pyridoacridines...收藏...
These oligomers are called triplex-forming oligonucleotides (TFO's) or TFO analogs. In a polypurine-polypyrimidine region, a purine-rich DNA single strand is hydrogen bonded by Watson-Crick base-pairing to a pyrimidine-rich DNA single strand; the polypurine-polypyrimidine region is not necessarily ...
Such schemes which have been described in the prior patent literature are discussed below. U.S. Pat. No. 6,320,018 describes the synthesis of a supramolecular subunit based on a ureidopyrimidine heterocycle which is self-complementary through a linear and coplanar AADD arrangement of hydrogen ...