We also show that site-specific cleavage within the MLL bcr can be linked to the higher-order chromatin fragmentation that occurs during the initial stages of apoptosis, possibly through cleavage of DNA loops at their anchorage sites to the nuclear matrix. In addition, we show that site-...
Background: The adhesion of two epithelial sheets is a fundamental process that occurs throughout embryogenesis and during wound repair. Sealing of the dor... A Jacinto,W Wood,T Balayo,... - 《Current Biology Cb》 被引量: 534发表: 2000年 ...
gigantica have temperate and tropical distributions, respectively, parasite sympatry occurs in parts of Asia and Africa. A growing protein demand has the potential to facilitate the translocation of parasites from endemic to non-endemic areas, via associated international livestock movements. Such is the...
The translocation channel formed by the α-subunit can accommodate α-helical structures but probably not larger structures. As a consequence, even the small, 17-kDa Semliki Forest virus capsid protein (Cp) cannot fold in the translocation pore. Rather, its native structure is attained only after...
Cloning of rth6 by a combination of BSR-Seq and Seq-walking. The rth6 gene was genetically mapped to the short arm of chromosome 1 by B-A translocation stocks. Subsequently, 123 mutant and 123 BwSilRd--Styeqp.eTihnidsivanidaulyaslissodfeamFo2n-mstraaptpedintghpatotphuelactaiuosnat...
Later, when WWOX loss occurs in cancer cells, hyaluronidase production is then increased in the cancer cells to facilitate metastasis. We determined that inhibition of membrane hyaluronidase Tyr216-phosphorylated Hyal-2 by antibody suppresses cancer growth in vivo. WWOX-negative (WWOX-) cells dodged ...
cardiotoxins across cobra species share a converging mechanism which includes the initial binding of cardiotoxins to CL of the OMM and the formation of short-range ionic, ion-dipole and hydrogen bonds with CL and PC of the OMM that drive further embedding into the OMM and translocation through...
to greater Gs and a significant increase in the photosynthetic capacity because the stomata were more likely to remain open. According to a previous study [43], stomatal limitation of the Pn occurs only when the Gs decreases in parallel with a decline in the Ci. In this study, the change ...
During poleward movement of the autosomes in anaphase, the bundled region shortens by about 0.25 microm for each 1 microm the chromosome moves poleward; this suggests that, during anaphase, 75% of the kinetochore microtubule shortening occurs atthe pole end. ...
Activation of the inflammasome occurs intracellularly where all components of the inflammasome machinery can interact upon activation [36]. Macrophages and microglia are phagocytic cells that can internalize and traffic Aβ to lysosomes, although microglia in the AD brain exhibit defects in lysosomal func...