The raw data were subjected to analysis by conventional RNA-Seq software, which pinpointed differentially expressed genes (DEGs). Gene Ontology (GO) and pathway enrichment analyses were performed in the subsequent step to identify the enriched biological processes and pathways from the differentially ...
This multimeric complex is responsible for ubiquitination-mediated degradation of target proteins involved in various biological processes [10]. A well-regulated SCF E3 ubiquitin ligase maintains homeostasis in cell proliferation and genome stability, hence preventing carcinogenesis [10]. Bortezomib was the...