The intestinal epithelium is more than just a physical barrier responsible for nutrient uptake; rather, it plays a critical role in homeostasis through its intrinsic, innate immune functions and maintains, under ideal circumstances, mutualistic and symbiotic relationships with a diverse and dynamic commun...
However, the underlying mechanisms and key factors involved in BRCA formation and disease advancement remains under-explored. By retrospective studies of BRCA patient tissues; and gene knockdown and gain/loss-of-function studies, we uncovered a novel E3 ligase, FBXL8, in BRCA. A signature ...