The patient had an ATM mutation, which is a gene associated with homologous recombination deficiency, and exhibited a good response against platinum-based chemotherapy and possible therapeutic target by poly(ADP-ribose) polymerase inhibitors. The Author(s) under exclusive licence to The Japan Society ...
Identification of a new nuclear gene (CEM1) encoding a protein homologous to a β‐keto‐acyl synthase which is essential for mitochondrial respiration in ... Slonimski, Identification of a new nuclear gene (CEM1) encoding a protein homologous to a beta-keto-acyl synthase which is essential ...
The region of the genome, hybridizing with cob exon probes is separated by an intervening sequence of about 2500 bp, which is homologous with the first... B.,Franz,Lang,... - 《Molecular & General Genetics Mgg》 被引量: 318发表: 1984年 Characterization of mature mitochondrial transcripts in...
which is homologous to a known recombinase gene, is transformed in a cell using a vector, and a DNA containing at least one modified gene G1 to Gn, or at least one mutation M1 to Mn, is inserted into the cell, and the cell that has highest metabolite production is identified by way ...
a) Mutations b) Sexual reproduction c) Asexual reproduction d) Lateral gene transfer Genetic variation Genome is not a static entity, it is dynamic in nature. a heritable change in the genetic material of an organism that giv...
The phage integrates into the chromosome of its Escherichia coli host strain, CB6220, within a gene that is homologous to gene Z2577 and encodes an oxidoreductase. This new integration site was found in different Stx1ox3-producing enterohemorrhagic E. coli strains, which were analyzed by PCR....
The nucleotide sequences of the coding regions of the genes are approximately 95% homologous, and neither gene contains an intervening sequence. Codon ... MJ Holland,JP Holland,GP Thill,... - 《Journal of Biological Chemistry》 被引量: 270发表: 1981年 Insulin Signaling and the Control of PH...
In term of function, a detailed analysis of the fosmid sequence revealed a cluster of ORFs homologous to genes encoding chemotactic signalling systems. Indeed, from ORF6 to ORF25 up to 13 genes related to chemotaxis and motility are represented, such as homologues of CheA (cytoplasmic histidine ...
The region of 30 amino acid residues next to the leucine repeats towards the N terminus is rich in basic amino acids and is also homologous to a domain present in fos, jun and GCN4. Moreover, in the carboxy terminal region an amino acid motif closely resembling a metal binding domain is...
recombinant DNAs containing a gene coding for a heat-stable alpha -amylase, which DNAs contain at least: - the DNA fragment of a Bacillus licheniformis strain, coding for a heat-stable alpha -amylase, and - a DNA fragment of a plasmid, of a phage lambda or of a phage lambda derivative...