In normal lung, TTF1-CCDC59 complex can transactivateSFTPBandSFTPCgene expression, which play an important role by regulating the alveolar surface tension29. But in COVID-19-affected lung,TTF1andSFTPCgenes were found to be downregulated, whereasSFTPBwas upregulated (Fig.3). GATA6 transcription...
In order to locate the degron more accurately, Nrf2 expression constructs were made in which the PEST sequence was deleted in two halves, N-PEST347–362 and SDS2 (that is, C-PEST363–379). Using COS1 cells, the contributions made by SDS1 and SDS2 to the association of Nrf2 with b-...
An increased frequency of IgG reactivity to EBNA1 was found in MS patients using a cDNA protein-expression array containing 37,000 tagged proteins (Cepok et al., 2005). The findings of this study are in accordance with previous reports on a higher frequency of CSF-derived EBNA1-specific IgG...
Analysis of existing HNSCC TCGA data indicates quite clearly that LDHA and LDHB expression is high across patient tumors and confined to a relative narrow spectrum of values (Fig. 4B). Figure 4 Cisplatin generated oxidative stress decreased reducing equivalent availability. (A) Cells were treated ...
Mdm2, an inhibitor of p53, is a target gene of AhR.29 To link between AhR and p53, we examined the effect of oltipraz treatment with or without miR-125b modulation on the expression of mdm2. Oltipraz increased the levels of mdm2, beginning from 3 h to at least 24 h after treatme...
aThe condition media (CM) from the stable transfectants of BCC cells, as described above, were used to carry out CAM assay using chick embryos.bEndogenous WWOX and ectopic EGFP and EGFP-WWOX proteins are shown in the stable transfectants.c, dExpression of bFGF protein is shown in the BCC...
as further inhibition of autophagy flux increased TMZ/Simva/ASH-induced cell death in GBM cells. Finally, our results showed that TMZ/Simva/ASH treatment potentially depends on an increase of Bax expression in GBM cells. Our current investigation might open new avenues for a more effective treat...
It becomes clearer and clearer that aging is a result of a significant number of causes and it would seem that counteracting one or several of them should not make a significant difference. Taken at face value, this suggests, for example, that free radic