PF determination was achieved successfully in human serum samples using this method, thereby avoiding interference from co-administered drugs, such as cisatracurium, which possess substantial overlap in their emission spectra. Compatible with a wide array of analytical techniques, the developed sample ...
However, there are potentially other approaches to delivery of genes encoding protein-based Ras inhibitors, including the rapidly developing fields of oncolytic virus33 and mRNA delivery34. In conclusion, the data reported here support nucleotide exchange inhibition as a valid mechanism of action to ...
A combination of the two protease inhibitors lupinavir and ritonavir was another option COVID-19 treatment (Nutho et al.2020). The use of these drugs in COVID-19 treatment basically has to do with the earlier confirmed success against SARS-CoV-1 virus and the coronavirus that causes MERS ...
Thanigaivelan, Sampoornam Balakrishnan, Karpagam Veerappan, Rasappan Periannan, Shila Samuel(2010). New Generation Novel Drugs Designed For Type 2 Diabetes By Insilico Computational Methods which block IRS4. Biomirror. Vol.1;bm-0408101510.
associated with low barrier to resistance of most marketed NS5A inhibitors for genotype 1 subtype a (GT1a)196, 197, 198 as well as improve the pharmacokinetic profiles of existing drugs by prodrug synthesis to enhance solubility properties and simplify drug dosage formulations (e.g., pibrentasvir...
Extracellular vesicles as shut- tles of tumor biomarkers and anti-tumor drugs. Front Oncol (2014) 4:267. doi:10.3389/fonc.2014.00267 6. Atay S, Godwin AK. Tumor-derived exosomes: a message delivery system for tumor progression. Commun Integr Biol (2014) 7(1):e28...
The treatment based on topical or oral administration of 5-aminolevulinic acid (5-ALA) and its methyl ester, which are precursor drugs leading to accumulation of endogenous protoporphyrin IX in cancer tissue, should be separately noted. The long list of non-porphyrin and porphyrin candidate PSs ...
In some cases, mutations of kinase-related signal molecule genes in cancer cells result in the resistance to tyrosine kinase inhibitor (TKI) drugs. Recently, it was revealed that k-ras mutations are significantly associated with a lack of response to epidermal growth factor receptor (EGFR) TKIs ...
Statins are a class of drugs used to lower high cholesterol levels and to prevent associated complications, for example, by treating cardiovascular diseases through inhibiting HMG-CoA reductase. However, statins have been associated with an increased risk of ICH.1,7–10 Atorvastatin can induce ...
The utilization of homo-FRET with both H-Ras and K-Ras derived constructs permits the sensitive detection of responses to Ras-lipidation and trafficking inhibitors, and likewise, genetic disruptions within proteins responsible for maintaining membrane anchorage. The BI-2852 Ras-dimerizing compound, ...