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Bempedoic acid is a drug that is taken orally and absorbed in the small intestine. Concomitant food intake had no effect on the oral bioavailability of the drug. The apparent volume of distribution (V/F) is approximately 18 liters, suggesting a distribution predominantly into the vascular compart...
Tacrolimus presents high intra and inter-individual variability in its blood trough concentration (Cmin). Knowledge of the factors that are involved in tacrolimus Cmin variability is thus clinically important to prevent or limit it. Inflammation can affect the pharmacokinetic properties of drugs. We ...