Hence, we show that microglia in the GBM microenvironment assist GBM cells to repair radiation induced DNA damage by secreting acetylated amino acids which are consumed by GBM cells and used to fuel the TCA cycle allowing utilization of glucose for nucleotide synthesis, thereby making the GBM ...
resulting in a silent alteration. Substitutes for an amino acid within the sequence may be selected from other members of the class to which the amino acid belongs. For example, the nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan...
Interestingly, CHD6 is essential for the oxidative stress response and also DNA damage repair [216], and so Nrf2 activity may be coordinated in some way with that of DNA repair. Lys residues in the Neh3 domain are also acetylated by CBP/p300 [217]. Neh4 and Neh5 (amino acids 112–...
Chitin digestibility can be estimated to some extent by Chia gene expression level in stomach as well as its chitinolytic activity. Our data showed that specific activity of Chia is as follows: mouse: chicken: pig: bovine: dog = 1.0: 0.7: 0.9: 0.25: 0.1. When those mRNA levels (nu...
This invention- relates to the manufacture of amides of aliphatic-aromatic acids in which there is an amine residue as a substituent at the amide-nitrogen. These new amides have valuable therapeutic properties, and approximate the atropine in value. The new amides may be made either by causing....
Preferred compounds include the phosphoric acids where x is 0, 1 or 2 (C3, 4 and 5, respectively) as well as disodium 3-sulpho-propionate (Is63) and its free acid, and 3-borono-propionic acid (Is62). The compounds of formula (E) are N-acylated amino acids or polycarboxylic acids...
nOe is carried out on an acetylated derivative of Ia. In a two dimensional nOe experiment (NOESY), noes are observed between an N-H proton at 8.06 ppm and the 5.17 proton (FIG. 4). The following structure has been elucidated for Ia ##STR3## It can be classified as a ureido ...
8. A purified peptide twenty-four or fewer amino acids in length, wherein the amino acid sequence of said peptide comprises the amino acid sequence of SEQ ID NO. 1. 9. The peptide of claim 8, wherein the amino acid sequence of said peptide consists of the amino acid sequence of SEQ...