Canada is most famous for its Yukon Territory and the part it played in the Klondike Gold Rush of 1896. Gold was first discovered in Canada in 1823 along the Riviere Chaudiere in eastern Quebec, then in the 1850s, most notably in 1858 when the Fraser River Gold Rush, or Cariboo Gold R...
With an enchanting way of weaving storytelling into recipes that then transitioned back into stories again, Maura’s cookbook was unique in that it read like both a recipe book and a storybook all in one. Growing up in County Kildare, Maura’s love of cooking began in childhood and was b...
I entered the hotel manager's office and sat down. I had just lost $50 and I felt very upset.' I left the money in my room,' I said, 'and it's not there now.' The manager was sympathetic, but he could do nothing. 'Everyone's losing money these days,' he said. He started ...
Crizotinib is an orally available drug which was originally discovered as a c-Met kinase inhibitor [98]. The compound binds the ATP pocket of MET kinase in a DFG-in conformation, forming classical hydrogen bonds (Hb) with hinge region residues [99]; in addition, its phenyl ring forms a ...