Although the methoxy and amide side chains of the melatonin molecule also contribute to its antioxidant capacity, the reactive center of interaction with free radicals is located in the indole moiety, due to its high resonance stability and very low activation energy barrier ...
It is well documented that in the chain from sample to the result in a clinical laboratory, the pre-analytical phase is the weakest and most vulnerable link. This also holds for the use and analysis of extracellular nucleic acids. In this short review, w
In the spleen, the percentage of neutrophils, M1 macrophages, IFN-γ + CD19 + B cells, IFN-γ + CD4 + T cells (Th1), and IL-17 + CD4 + T cells (Th17) was significantly decreased in hUC-MSC-treated mice (Figure 5) [62]. Figure 5. Anti-inflammatory and immunomodulatory effects ...
Possible circadian regulation of extrapineal melatonin production (bottom) in the retina, liver, brain, thymus, and spleen. A possible interplay with pineal melatonin has been suggested (yellow arrows). Retina is able to uptake melatonin from exogenous administration, while pineal melatonin seems to ...