In a detailed manner, it is hypothesized that S protein, which is produced as a result of immunization against SARS-CoV-2, can bind to the sialic acid located on the gangliosides and glycoproteins of the neurons’ cell membrane. Therefore, antibodies attacking to S proteins might also respond...
This isoform was found to be addressed specifically to nerve endings, whereas VATPases in the neuron cell bodies contain a different asubunit isoform. In nerve terminals, the V-ATPase membrane domain is present not only in synaptic vesicles but also in the presynaptic plasma membrane, where ...
Alzheimer s disease (AD) is characterized by cerebral deposition of β-amyloid peptide (Aβ). Aβ is produced by sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Many studies have demonstrated that the internalization
There are many cellular events that occur to cause a muscle contraction. Answer and Explanation: Become a Study.com member to unlock this answer! Create your account View this answer The neuromuscular junction is the region where the motor neuron comes into c...
The complement system is a set of immune proteins involved in first-line defense against pathogens and removal of waste materials. Recent evidence has implicated the complement cascade in diseases involving the central nervous system, including schizophrenia. Here, we provide an up-to-date narrative ...
Investigations into the proteolytic processing of amyloid precursor protein (APP) have provided insights into both the pathogenesis of Alzheimer's disease and an unusual form of regulated proteolytic processing within the membrane-spanning domains of sev
Al- though we had expected APP to traffic to the lysosome primarily via the plasma membrane, instead we observed rapid transport of APP to a LAMP1 compartment within seconds, similar to the behavior of LAMP1 [30]. Fur- thermore, we were able to follow the clearance of βAPP-paGFP in ...
the extracellular sites. The plasma membrane glucose transporters of this family are designated as GLUT1-4 [18,19]. GLUT5 is a transporter of fructose [20]. GLUT6 is a nonfunctional pseudogene [21], while GLUT7 is a hepatic endoplasmic reticulum glucose transporter [22]. The function of ...
Dio3 is an integral membrane protein, which, in the brain, is found in neurons. Its catalytic domain is thought to be inside the plasma membrane, where it catalyzes the inner ring deiodination of T3, rendering it inactive before it reaches the nucleus [11,12] . The lack of Dio3 leads ...