Alzheimer s disease (AD) is characterized by cerebral deposition of β-amyloid peptide (Aβ). Aβ is produced by sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Many studies have demonstrated that the internalization
Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid Joshua HK Tam1,3, Claudia Seah1 and Stephen H Pasternak1,2,3* Abstract Background: Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid peptide (Aβ...