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contortus genome has been undertaken, mostly towards discovery of drug or vaccine targets and include cytochrome P450 genes (Laing et al., 2015), kinases (Stroehlein et al., 2015) and aminopeptidases (Mohandas et al., 2016). This work is further reviewed in Gasser et al. (2016). Allied ...
Klionsky's laboratory pioneered the work on the selective autophagy-like process in yeast, the biosynthetic cytoplasm-to-vacuole targeting (Cvt) pathway, which is responsible for delivery of resident hydrolases, aminopeptidase I (Ape1) and α-mannosidase (Ams1), to the vacuole [47], [48]. (...
This ligand binds explicitly to aminopeptidase N (CD13), expressed on the endothelial cells of newly forming blood vessels and some tumor cells. NLCs modified in this way (DHA-NGR/CCNLC) showed excellent tumor-targeting capabilities and efficient accumulation in tumor tissue, as confirmed by both...