Screening for covalent hits from an electrophile-first approach targeting cysteine residues, using intact protein mass spectrometry has been exemplified on multiple targets, for example papain [64], the E3 ubiquitin ligase HOIP [73], peptidylprolyl cis/trans isomerase NIMA-interacting 1 (Pin1) [74]...
Commonwealth of Independent States (CIS) 60 2.9 48 81.4 11 18.6 0 0 0 0.0 0 0.0 Africa 33 1.6 29 87.9 4 12.1 14 2.1 12 85.7 2 14.3 Arab States 33 1.6 29 87.9 4 12.1 625 95.3 362 58.6 256 41.4 Gender. Respondents were asked about their gender and, as shown in Table 2, nearly...
Should we burden the predominate writing population (read as white, cis, heterosexual males) with the solution? It might seem blasphemous, but I say no. Critics quibble with any act an author makes, binding them to a strict biological essentialism. They say a writer’s female or ethnic chara...
researcher. And some refer to my appearance—for example, short. I identify as a woman, and most people identify me as a cis-woman after assessing the shape of my body, the timbre of my voice, and the way in which I dress which they associate with femininity....
they constructed a UniCAR epitope in combination with PSMA-11 to generate a compound that redirects UniCAR T cells to tumor cells. The advantage of UniCAR T cells is that bispecific bridging molecules, called target modules, could mediate them and do not interact directly with tumor cells like ...
Participants were 18–24 years old, all identified as cisgender male, three-quarters as gay and a quarter as bisexual. Themes that were defined from the analysis included: YMSM’s experiences during healthcare seeking in various clinical settings, priority health needs, desired healthcare provider...
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The reason this is important it two fold. One, if a writer’s aim is for their story to be rooted in reality, their characters have to be as much like people as possible – and the default model human is not white, cis, healthy, prime-aged American male. That’s actually a much ...
Author of Where Do We Go From Here?, The Imperfection of Us, Perfectly Ordinary People, From Something Old, The Road to Zoe, You Then Me Now, Things We Never Said, The Bottle of Tears, The Other Son, The Photographer's Wife, The Half-Life of Hannah, the
Author of Where Do We Go From Here?, The Imperfection of Us, Perfectly Ordinary People, From Something Old, The Road to Zoe, You Then Me Now, Things We Never Said, The Bottle of Tears, The Other Son, The Photographer's Wife, The Half-Life of Hannah, the