The angiotensin-converting enzyme 2 (ACE2), renin-aldosterone system (RAAS), and kinin-kallikrein system are the main proposed mechanisms contributing to cardiovascular complications with the COVID-19 infection. ACE receptors can be found in th...
Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates. Proc Natl Acad Sci USA. 2020;117(36):22311–22. https://doi.org/10.1073/pnas.2010146117. Article CAS PubMed PubMed Central Google Scholar de Oliveira RC, Fernandes J, Gonçalves-...
The novel coronavirus uses its spike protein to bind to ACE2 receptors on human cells and subsequently infect them. Therefore, scientists have chosen to focus on the spike protein as one of the major targets for vaccines and therapeutics. The Institute of Microbiology said its recombinant protein ...
SARS-CoV-2 causes viremia and binds the ACE2 receptors in the lungs, gastrointestinal tract, heart, vascular endothelium, kidneys, liver, and brain.117 The main symptoms include fever, cough, fatigue, myalgia, pharyngodynia, diarrhea, anosmia, and ageusia.118, 119, 120, 121, 122 More ...
Detailed analysis of the protein sequence data has also indicated the potential of pangolins, turtles, and snakes acting as intermediate hosts of SARS-CoV-2, owing to the presence of ACE2 receptors in the CoVs reported from these animals (Guan et al., 2020). A recent study has used ...
[137]. In patients with BK virus-associated nephritis, NK cells possessed lower KIR3DS1 activating receptors than a control group of recipients negative for BK virus infection. Researchers also found that the telomeric part of KIR haplotypes is associated with infection, suggesting an NK cell ...
Cannabidiol (CBD) is a chemical found in hemp or marijuana plants that does not make users high. Despite CBD only being approved by the US Food and Drug Administration (FDA) to treat rare forms of childhood epilepsy, CBD has been widelymarketed as a cure-allunder the auspices of ...
Therefore, blocking of the isolated viral S protein at its host receptor region and/or binding within the S protein-ACE2 interface are the two most important strategies to design probable drugs for COVID-19 (Fig. 1b) [9]. The SARS-CoV-2 virus replicates via multiple processes after ...
2005). The similarity in the mechanism of interactions by different RBDs toward the ACE2 receptor is demonstrated by the crystal structure of RBDs of SARS-CoV-2 and SARS-CoV complexing with the hACE2 (Lan et al. 2020; Li et al. 2005). These two RBDs are considered to share 14 ...