Huntington's Disease (HD) is a late-onset and progressive neurodegenerative disease of the central nervous system with autosomal dominant inheritance. The prevalence of the disease is about 1/100 000 among individuals of European descent. The clinical symptoms of HD involve motor dysfunction, ...
Huntington's disease is caused by a single dominant allele and results in progressive mental and neurological damage. The disease usually becomes symptomatic when a person is between 30 and 50 years old and the patient usually dies within 15 years of diagnosis. Approximately 1 in 25,000 Caucasian...
People with Huntington's disease (HD) commonly report difficulty carrying out two everyday tasks simultaneously. This difficulty, confirmed by experimental studies, is typically ascribed to impaired attention. Yet, dual-task problems extend to relatively simple tasks, such as walking and talking, which...
Hi. I'm Dr Karen Anderson. I'm the director of the Huntington's Disease Care, Education and Research Center at Georgetown MedStar University Hospital. Today we're going to talk about Huntington disease and the apathy and irritability-aggression conundrum. It is an interesting thing in Huntingto...
The experience of children who are raised in a family where a parent has Huntington's Disease (HD) is complex. The purpose of this project was to explore the resiliency of those who were raised in a family with a parent who had HD, explore the effect the gender of the child had on ...
Predictive testing for Huntington disease (HD) in 25% at-risk individuals is testing with full knowledge, and sometimes assuming, that the parent does not want to know his status. The goal of this study was to understand: (1) the differences in the motivation between 25% and 50% at-risk...
This paper recognizes the complexity of the debate on informed consent and discusses the importance of the ongoing process of consent for people affected by Huntington's disease (HD). Although written information may not be the most appropriate form of obtaining informed consent in qualitative researc...
Huntington's disease, disease onset, unified Huntington's disease rating scale, diagnostic confidence intervalBackground Determination of disease onset in Huntington's Disease is made by clinical experience. The Diagnostic Confidence Level is an assessment regarding the certainty about the clinical ...
Likewise, well-controlled intervention studies are often impractical in the setting of established neurodegenerative disease. It is this that makes understanding sleep and circadian abnormalities in Huntington's disease (HD) important: as a monogenic fully penetrant neurodegenerative condition presenting in ...
In the past few years, mounting evidence indicates that microRNAs (miRNAs)-mediated post-transcriptional regulation of gene expression represents an integral part of the autophagy regulatory network and may have a substantial effect on autophagy-related physiological......