Microgliosis, described first by Alois Alzheimer himself, was considered initially the consequence of AD pathology rather than a cause [20]. However, accumulating data have proven that neuroinflammation contributes both to disease initiation and progression. The crucial role of microglia in AD ...
19]. Microgliosis, described first by Alois Alzheimer himself, was considered initially the consequence of AD pathology rather than a cause [20]. However, accumulating data have proven that neuroinflammation contributes
The agonist selected for BDC-1001 was much less active, so the dose creeps to 12 mg/kg Q2W did not result in a DLT, but also did not result in a good clinical response. As pioneers in the field of ISAC, the failure of these two companies has left the future of ISAC in limbo....
The highest SLP (~1.13 kW/gFe in AMF of 23.8 kA/m and 710 kHz) was measured in water suspension of MC_NPs with the largest core size (i.e., 23 nm). This value was 5 times larger than that of MC_NPs with cores of 15 nm and 1.5 times larger than the 36 nm single-core NPs...
ImageJ software was used to measure the intensity of the LtxA spots to create an intensity vs. LtxA concentration curve to which the intensity of the OMV and cell spots could be compared. Using this method, we calculated that LtxA comprised approximately 40% (by mass) of the protein ...