These data indicate that UCHL3, rather than DNA-PKcs, is likely the target of farrerol. Next, to determine the affinity of farrerol to UCHL3, we performed SPR experiments using recombinant UCHL3 and farrerol at different concentrations. The results revealed a strong interaction between farrerol...
Triple-negative breast cancer—defined by the absence of oestrogen/progesterone receptors and human epidermal growth factor receptor 2 expression—is a complex and heterogeneous type of tumour characterised by poor prognosis, aggressive behaviour and lack of effective therapeutic strategies. The identification...
View on microRNAs as a potential tool to fight blindness: Focus on Müller glia and gliosis. Neural Regen. Res. 2022, 17, 1501–1502. [Google Scholar] [CrossRef] Friedman, R.C.; Farh, K.K.; Burge, C.B.; Bartel, D.P. Most mammalian mRNAs are conserved targets of microRNAs. ...