- 《Alzheimers & Dementia》 被引量: 46发表: 2010年 SMALL WORLD NETWORK MEASURES PREDICT WHITE MATTER DEGENERATION IN PATIENTS WITH EARLY-STAGE MILD COGNITIVE IMPAIRMENT Alzheimer's Disease (AD) has long been considered a cortical degenerative disease, but impaired brain connectivity, due to white ...
It was published in Alzheimer’s and Dementia Journal “if you are conscientious with a positive well-being, a good attitude and have a high level of life satisfaction, you are less likely to be diagnosed with dementia.” Millions of people were studied. The more negative and neurotic you a...
The production capacity of this pathway is under genetic control and offspring with a parental history of late-onset AD have a higher production capacity for pro-inflammatory cytokines. The activation of microglia by fibrillar A尾 deposits in the early preclinical stages of AD can make the brain ...
While the 5xFAD model has obvious limitations, such as the lack of deposition of other misfolded proteins, this model, and the choice of mouse age in our experiments, may represent a relatively early stage of late-onset AD, with amyloid accumulation and gliosis. Our findings are compatible ...
Sex is the other universal biological variable of AD, as females exhibit an almost two-fold greater lifetime AD risk and greater dementia burden compared to males (Barnes et al., 2005; Andersen et al., 1999; Oveisgharan et al., 2018; Vest and Pike, 2013). Underappreciated until ...
If there is a reason to consider the potential effects of gonadal hormones on an outcome of interest such as PPI, it is most straightforward to study all female participants in the early to mid-follicular phase when the vast majority of women will have relatively low levels of estradiol and ...
and the choice of mouse age in our experiments, may represent a relatively early stage of late-onset AD, with amyloid accumulation and gliosis. Our findings are compatible with the literature on the early involvement of infections in AD pathogenesis, which may affect the aging population who d...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an early-onset genetic form of subcortical ischemic vascular dementia that resembles sporadic small-vessel disease similar to VaD. Th... P Vinall,M Dichgans - 《Md Conference Express》 被引量: 245发...
The diagnosis of young-onset dementia presents significant challenges both for the person and their families, which often differ from the challenges faced with late-onset dementia. Evidence of the experience of service users and carers tends to reveal a negative appraisal of the care received, ...
Dementias are not perfectly differentiated. When we explain them to patients and families, we give thejdl688example of the intersection diagrams. Pure Alzheimer’s is considered to be 25% of cases; the rest are mixtures of this with dementia due to the accumulation of Lewy bodies or vascular ...