Bolla , M. et al . Duration of androgen suppression in the treatment of prostate cancer .. 2009 Nature Publishing Groupdoi:10.1038/nrurol.2009.131FarleySuzanne J.Nature Reviews UrologySuzanne J. Farley. (2009) Prostate cancer: ADT—who, when and for how long?. Nature Reviews Urology 6 , ...
While surgery and palliative care may seem mutually exclusive, surgeons have historically led the movement in palliative care as evidenced by landmark operations originally aimed to palliate suffering. Despite such foundations, awareness and application of palliative care by surgeons have been inconsistent...
Prostate cancer (PC) remains the most commonly diagnosed cancer in men worldwide [1] and therapeutic interventions are various, because of its heterogeneity [2]. At early stage, PC is prevalently treated with radical prostatectomy, brachytherapy, cryotherapy [3] and focal therapies [4,5]. This...
A central facet of cancer cell metabolism is a shift in glucose usage away from oxidative phosphorylation toward biosynthetic reactions. Without compensation by fatty acid oxidation (FAO) and glutaminolysis, this shift would result in deficiencies in citric acid cycle intermediates needed for ATP ...
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well as in testes and prostate-tumor tissues. In locally advanced and metastatic prostate cancer, antiandrogens such as Bicalutamide and Flutamide are used to interfere with the signaling of AR and can be combined with ADT in a therapeutic asset known as Combined Androgen Blockade (CAB) [5]....
randomized patients with locally advanced prostate cancer to ADT, versus radiation therapy and ADT (LHRH agonist used in 92% and orchiectomy in 8% of patients), and showed that the combined therapy resulted in better survival [14]. Thus, combining LHRH agonist with radiation for locally advanced...
Glucuronidation, catalyzed by UDP-glucuronosyltransferase UGT2B enzymes, is a major inactivating and elimination pathway for androgen hormones in humans. Whether Ugt2b enzymes from mice are also reactive with these hormones have never been investigated. The present study aimed at evaluating the capabili...