Malignant brain tumors affect people of all ages and are the second leading cause of cancer deaths in children. While current treatments are effective and improve survival, there remains a substantial need for more efficacious therapeutic modalities. The ketogenic diet (KD) - a high-fat, low-carb...
NAD+ levels are increased in fasting, intermittent fasting or caloric restriction, leading to the activation of sirtuins. Activated sirtuins deacetylate a number of proteins playing key roles in metabolism, inflammation, autophagy, aging, apoptosis, oxidative stress, neurodegeneration and cancer [286,...