How is pH returned to normal in patients with metabolic acidosis? Why does the enzyme function depend on temperature and pH homeostasis? What is the role of the blood in the regulation of pH of the body? What is the role of blood in the regulation of the pH of the body?
Why does heating up a protein such as an enzyme cause it to lose function? Why is glucose not present in urine? Why are proteins not present? In addition, why is K+ more concentrated in urine than filtrate? What is the process where proteins lose their structure? ...
Thermolysin is synthesised as a pre-proenzyme, with an N-terminal prosequence of 204 residues and a mature sequence of 316 residues. The prosequence facilitates the folding of the denatured mature sequence in vitro and the cleavage of the peptide bond linking the pro and mature sequences ...
Human amniotic epithelial cells (hAECs) maintain the plasticity of pregastrulation embryonic cells, having the potential to differentiate into all three germ layers. The potential of these cells to differentiate into cells expressing germ cell specific m
These results indicated that HSPs bound to denatured and unfold proteins to refold them under heat stress. Moreover, calreticulin (spot 1), a major endoplasmic reticulum Ca2+ binding chaperone, plays an essential role in regulating intracellular Ca2+ homeostasis55. In our study, calreticulin was ...
an E2 enzyme [3]. 11 members have been identified, and their structure is relatively conserved. Most MARCH family proteins have similar structures: with an amino-terminal RING finger domain, also known as the RING-CH domain, followed by zero, two, or more C-terminal transmembrane domains. ...
Denatured virions were incubated with PNGase F and subjected to western analyses using anti-AgseF and anti-CpF antiserum, respectively. Deglycosylation of HaF from vAc▵gp64-HaF was used as a positive control (Fig. 4B; lane 1 and 2). As shown in Fig. 4B, both AgseF (lane 3 and 4...
We performed in vitro and in vivo deubiquitination assay to establish that farrerol directly stimulates UCHL3 enzyme activity and promotes HR by UCHL3-RAD51 axis. In addition, HR is essential for the maintenance of genomic integrity51, whereas impaired HR leads to aneuploidy and cell cycle ...
modified the surface of liposome-encapsulated albumin nanoparticles containing paclitaxel with both an enzyme-responsive peptide (fibroblast-activated protein-a responsive cleavable amphiphilic peptide) and a photothermal agent (IR-780) to increase the therapeutic efficacy of the system against pancreatic ...