Using cryo-EM, the structure of the large Tra1 subunit and its anchoring to the rest of the SAGA complex was determined a few years ago [50,51]. Over 20 years after SAGA discovery, two recent reports finally pr
The snow started falling on the forest in New England, while I am working on this “honorable” invited review manuscript for “Insights from leading experts” collection. As a serious physician investigator, “how to choose research topics” has been always in the center of my mind for mysel...
This suggests a science to implementation gap. Smartphone apps can be built much more quickly than they can be tested rigorously. Randomized-controlled trials take an average of five and a half years to conduct and publish findings [38], whereas the average time to develop a mobile app is ...
months or even years.24,25,33 Although there are some data about the preven- tion of cisplatin neurotoxicity with utilization of vitamin E and amifostine, a Cochrane meta-analysis could not find any beneficial effects of preventive strategies.55 Oxaliplatin is a new type of...
In this context, providing data on the residual effective number of breeders and on their genetic make-up is crucial. From April and August 2015, unexpectedly, more than 3000 juveniles were recorded in the Yangtze estuary potentially representing the most relevant signal of spawning in 10 years,...
Credit for bringing Zen to America is always given to Daisetz Suzuki, who in turn influenced popularizers like Alan Watts. As Kay Larson notes in her wonderful bookWhere the Heart Beats, the musician John Cage also did much to explicate Suzuki’s ideas for the art world, not only in his...
Based on these data, the inhibition of IDO1 has become an exciting approach as cancer immunotherapy and IDO1 inhibitors have been intensively investigated during the recent years. Multiple IDO1 inhibitors with different structural skeleton have been developed[57,58,59,60,61,62,63,64,65,66,67]...
In the years since he retired from baseball in 2009, Petey has returned to Boston many times, and each time his impending arrival has sparked a buzz in the city. Anytime he was spotted, whether he was getting a haircut in Jamaica Plain or handing out free ice cream, you could always ...
of view. Nevertheless, the outlook into the future is a negative one. Just about 3 years after the emergence of SARS-CoV-2, it seems politicians and governments have forgotten that the pandemic existed and very little is spent—e.g., in comparison to defense—on pandemic preparedness. This...
The failure in the control of the pathogens by the immune system may lead to their uncontrolled systemic dissemination through the bloodstream and may cause a severe pleiomorphic syndrome, which is known as sepsis [23]. The definition of sepsis has undergone several changes over the years as a...