Among the most promising advances in phage therapy is the isolation of phage-encoded lytic enzymes, which opens the possibility for the development of novel phage-based pharmaceuticals [51]. Moreover, bacteriophages can also act synergistically with classical antibiotics and have enzymes on their ...
but also extended-spectrum beta-lactamase (ESBL) mechanisms with a possible link between high resistance and community antibiotic misuse [16]. In addition, ESBLEnterobacteriaceaespp. are responsible for outbreaks irrespective of location. Antibiotic ...
Although the new analogues of existing classes, and novel combinations, have been designed to address specific resistance problems, it is by no means certain than they will not be affected by the general mechanisms of resistance, particularly decreased net flux across the Gram-negative outer ...
Overall, although there is some clustering according to the year of isolation, geographical origin (on country level) appears to correlate better with clustering results than the isolation date. On a regional level, the German isolates did not show a strong clustering behaviour according to the ...
Table 2. Clinical characteristics of patients with mutant KPC-Kp. Eight patients (47.0%) underwent large-spectrum antibiotic treatment before mutant-KPC-Kp isolation, and only four patients (23.5%) underwent prior treatment with C/A as detailed in Table 1. All patients previously treated with C...