The creation of insulin in the beta cells of the pancreas is a two step procedure. Beta cells first produce preproinsulin. Preproinsulin is cleaved to create proinsulin, which is further cleaved to produce equal amounts of insulin and C-peptide. Endogenous (self-produced) insulin has a half-...
Long-acting insulin analogs that are currently available areinsulin detemir (Levemir) andinsulin glargine(Lantus,Semglee,Toujeo Solostar), and insulin glargine-aglr (Rezvoglar Kwikpen), a biosimilar to Lantus that is interchangeable with it.
There is only one type of intermediate-acting insulin on the market—neutral protamine Hagedorn (NPH). The duration of NPH can vary significantly, so it's not uncommon for people who use it to also take a dose of regular or rapid-acting insulin to cover meals.8 NPH looks different from ...
Official answer: Humalog and Novolog are both rapid acting forms of insulin that work for short periods of time; however, Humalog is...
for fasting plasma glucose compared with standard care on CV outcomes in people with pre- or early diabetes, and demonstrated a neutral effect on CV outcomes with long-term use of insulin glargine early in the course of diabetes, with a low rate of severe hypoglycaemia and modest weight gain...
With the availability of second-generation basal insulin analogs, insulin degludec (100 and 200 units/ml [degludec]) and insulin glargine 300 units/ml (gla... SC D'Souza,DF Kruger - 《Diabetes Therapy》 被引量: 0发表: 2020年 Overcoming Cultural Barriers to Diabetes Control: A Qualitative St...
Another factor affecting Lantus® dosage is how often the medication needs to be administered. In most cases, the insulin is given once daily, typically at the same time everyday. The medication can be given in this fashion because it exerts a constant, low-level effect on how the body ...
/QALY (2-dose regime) and 41,636 ?/QALY (3-dose regime) is estimated.ConclusionsExtension of the ... J Olsen,T J?Rgensen - 《Cost Effectiveness & Resource Allocation》 被引量: 28发表: 2015年 Cost-effectiveness of insulin glargine versus NPH insulin for the treatment of Type 2 diabetes...
Comparison of insulin detemir and insulin glargine in a basal—bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes... value 鈮 11.0% at screening. Patients were randomized in a 2:1 ratio to receive either detemir or glargine for 52 weeks. The basal...
There has been for 3years controversy on the potential increased risk for cancer with insulin glargine, which ceased with the publication of the ORIGIN trial in 2012. In insulin-treated persons with type 2 diabetes, it is usual to recommend that plasma insulin concentrations remain within a 50...