The analysis of cellular ultrastructure is paramount for gaining a comprehensive understanding of cell functionality. By examining the intricate details within a cell, researchers can uncover the mechanisms that drive various cellular processes and functions. However, differentiating between organelles, membran...
The analysis of cellular ultrastructure is paramount for gaining a comprehensive understanding of cell functionality. By examining the intricate details within a cell, researchers can uncover the mechanisms that drive various cellular processes and functions. ...
What is gene therapy, what is the gene composed of and how can we use gene therapy in the long run? Oxidation of which type of biomolecule provides the greatest energy per gram? a. lipid b. protein c. nucleic acid d. carbohydrate ...
Stochastic encounters subsequently made with self-ligands during positive selection in the thymus imprint functional biases that a T cell will carry with it throughout its lifetime, although ongoing interactions with self in the periphery ensure a level of plasticity in the gene expression wiring of...
Green AD, Vasu S, McClenaghan NH, Flatt PR . Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells. Pflugers Arch 2015; 467: 2219–2228. Article CAS Google Scholar Lecomte MJ, Pechberty S, Machado C, Da ...
12-O-Tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region Mol. Cell Biol., 7 (1987), pp. 2256-2266 View in ScopusGoogle Scholar Auble and Brinckerhoff, 1991 D.T. Auble, C.E. Brinckerhoff ...
The phenomenon of oxidative stress, characterized as an imbalance in the production of reactive oxygen species and antioxidant responses, is a well-known inflammatory mechanism and constitutes an important cellular process. The relationship of viral infections, reactive species production, oxidative stress,...
Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple ...
In this review, we discuss evidence for the signaling pathways and cellular processes stemming from TTCC activity, mainly inferred by inverse reasoning from pharmacological blocks and, only in a few studies, by gene silencing or channel activation. A thorough analysis indicates that drug-induced ...
Until the recent approval of sotorasib, a KRAS G12C inhibitor, lack of targeted therapy for KRAS has resulted in poor prognosis of patients with tumors harboring KRAS mutations [1]. The KRAS protein is a GTPase that transmits intracellular signals upon binding to GTP [2], [3]. Under ...