Triple negative breast cancer (TNBC) means that the cancer cells do not have estrogen (ER) and progesterone (PR) on their surface, and they do not over-express the HER2 protein as well (HER2−). In contrast to TNBC, triple positive breast cancer means the cancer cells are ER+, PR+,...
The relative breast cancer survival rate will also be different between people who are AMAB and those who are AFAB: Localized breast cancer is only in the breast. This includes stage IA (pronounced “stage 1-A”), some IIA (“stage 2-A”), and some IIB (“stage 2-B”). For people...
Trastuzumab is indicated for: HER2-positive metastatic breast cancer Early-stage breast cancer HER2-positive early-stage breast cancer Adjuvant therapy in combination with docetaxel and carboplatin Neoadjuvant therapy followed by adjuvant therapy for locally advanced (including inflammatory) or tumor size >2...
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The next day I went in for the biopsy and, a few days later, was stunned to find out I had stage two HER2-positive breast cancer (HER2 stands for human epidermal growth factor receptor). Not only did I have breast cancer, but I also had one of the most aggressive forms of the ...
The next day I went in for the biopsy and, a few days later, was stunned to find out I had stage two HER2-positive breast cancer (HER2 stands for human epidermal growth factor receptor). Not only did I have breast cancer, but I also had one of the most aggressive forms of the ...
Trastuzumab is a targeted therapy for human EGF receptor-2 (HER2)-positive breast cancer. The effectiveness and cost–effectiveness of trastuzumab hinges not only on its clinical efficacy in responding patients, but on the ability to accurately identify appropriate therapeutic candidates. We sought to...
Stage 2The cancer has begun to grow but it remains only in the breast or nearby lymph nodes. Treatment is not usually very difficult. Stage 3The cancer has begun invading lymph nodes, muscle, and other body tissue near the breast, but it has not reached organs farther away. Treatments var...
Mutations and amplification of the HER2 gene can lead to excessive presence (overexpression) of HER2 proteins on the cell surface, a major cause forbreast cancer. Cancers caused by HER oncogenes include: HER2 positive breast cancer Non-small-cell lung carcinoma ...