Abnormal tumor microenvironment and immune escape in multiple myeloma (MM) are associated with regulatory T cells (Tregs), which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells.
Multiple myeloma (MM) is the most common form of plasma cell malignancy, accounting for about 1.7% of all malignant tumors [1]. Although the use of a variety of treatment options such as high-dose chemotherapy, hematopoietic stem cell transplantation (HSCT), proteasome inhibitors (PIs), immunom...
Health-service issues and QOL The present study demonstrates the importance of health- service issues in determining the QOL of myeloma patients. Such issues have also been reported as important in other qualitative studies in myeloma [26,27,29,30], making a case for the inclusion of related ...
Immunomodulatory drugs (IMiDs) have become an integral part of therapy for both newly diagnosed and relapsed/refractory multiple myeloma (RRMM). IMiDs bind to cereblon, leading to the degradation of proteins involved in B-cell survival and proliferation. Thalidomide, a first-generation IMiD, has lit...
If you have relapsed or refractory multiple myeloma, you might be a good fit for CAR T-cell therapy. It's a specialized treatment that involves genetically changing your immune cells and training them to kill the cancer. It has the potential to be very effective, but like most things, ther...
Let us discuss the factors that might have impacted MUR’s quarterly performance. Factors Likely to Have Impacted MUR’s Q4 Results Murphy Oil’s fourth-quarter earnings are expected to have benefited from the production ramp-up in its domestic and international assets. The company benefited from...
Mr. Savage I would also like to know of a way you might have to help. I can tell you more of my story if you need to know. Thank You, Beth Harris Michael Cook August 9, 2013 From the arctic to the tropics there are people who never get cancer. The Innuit (Eskimo’s) until...
This can complicate the treatment process of myeloma in the elderly, since NP may present as bradycardia and also consti- pation and impotence.74 Lenalidomide is a second-generation drug with more potency but less neurotoxicity.75 Bortezomib is a member of a new class of ...
Consequently, the impact of a single mutation along the interface may not be enough to disrupt oligomer formation, but multiple mutations may be required. Alternatively, identification of the few key polar contacts (if present) only found in the top or bottom of the helices is key (Ferré et...
Furthermore, there might also exist subsets of patients in the data that live longer than the general population, thus violating the key assumption of relative survival, i.e. that there exists an excess hazard (the overall hazard of the patients is higher than the population hazard). This ma...