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Independently from the invasion route, glioma cells show a mesenchymal type of migration and must often cross extracellular spaces smaller than their nucleus. Specifically, glioma cells become fibroblast-like and polarized, with leading and trailing edges located at the opposite sites of the cell body...
However, upon stimulation, the inhibitory proteins are degraded, allowing the NF-κB complex to translocate to the nucleus; once in the nucleus, it triggers the transcription of several genes, with a particular emphasis on pro-inflammatory genes [44]. Previous studies have shown that the age-...
During the late stages of atherosclerosis development, these cells obtain a stable fibrous membrane that divides them from the vessel milieu. The violation of the stability of the plaque happens due to the exhaustion and tear of the fibrous membrane, which is facilitated by matrix metalloproteinases...