The latter has been shown in elegant work by the Pollard and Karin labs to involve the host innate immune system and specifically macrophages (Grivennikov et al., 2010, Qian and Pollard, 2010). In 2005, we reported that ET-1 secreted by tumors with low levels of the RhoGDI2 metastasis...
Studies using these mice have provided a unique and innovative strategy by which labs with interests from addiction to reproductive behaviors have been able to address important questions regarding sex differences independent of gonadal hormones. For example, Jane Taylor’s group, as discussed below, ...