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Instagram is a fast-paced environment where posts and stories disappear within 24 hours. Keeping communication quick and efficient is key, which is why acronyms like TMB gain traction. Additionally, Instagram’s comment sections, captions, and DMs are typically designed for brief interactions, making...
Based on the clinical trial information, PD-L1 expression, tumor mutation burden (TMB), microsatellite instability-high (MSI-H) and mismatch-repair deficiency (MMR) have been identified as predictive biomarkers for anti-PD-1/PD-L1 antibody therapies[107,108,109,110,111]. Although biomarkers of...
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而肿瘤突变负荷(TMB)尽管前景良好,但作为肺癌获益预测因素的数据不一致。也从分子因素上来判断获益人群,比如存在EGFR、ALK(ROS1)突变的人群可以从免疫治疗获益人群中排除,KRAS突变是否能够成为获益预测因子,相关数据仍未经前瞻性数据验证,有研究显示基因共突变可能介导免疫治疗疗效,例如:TP53(+)、STK11和KEAP1(-)。
He shares his own experience about obtaining medical history from a new patient and states that, getting a patient to open up about his medical history is an art, learned through trial and error. He also believes that pharmacology knowledge is helpful when patients are not open about giving ...
Tumor Mutational Burden-High (TMB-H) Cancer (cancers that have many gene mutations) cancers that laboratory testing proves to have certain specific DNA mutations In clinical studies of the cancer types that Keytruda is approved to treat, researchers studied groups of patients to better understand ho...
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MSI is due to MMR deletion or gene replication process deletion or error, leading to changes in the length of MS. TMB refers to tumor mutational burden, representing the number of mutations per million bases. Both MSI and TMB represent the production of new antibodies. Studies have stated clea...