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Despite the aggressiveness of the treatment, involving radio- and chemo-therapy after a maximal surgical resection, GBM patients show a median survival of 14 months [2]. One of the peculiarity of GBM, hindering the efficacy of treatments, is the diffuse invasion of tumour cells into the ...
Hypofractionation radiotherapy with Temozolomide can achieve 9–20 months of survival in elderly patients (compared to 6–8 months with standard radiotherapy). However, more research is required to adjust the fractionation regimen and increase the survival rate and quality of life of patients. ...
reported an opposite result, founding that P4 has no impact on the proliferation rate of human umbilical vein endothelial cells (HUVECs), a macrovascular cell model used for endothelial studies in vitro [43]. An anti-angiogenic role of progestogens has been reported in several studies. Okada ...
We must also note the pharmacokinetics of curcumin. Curcumin is lipophilic, which is beneficial for absorption because it will aid in penetrating lipid membranes. However, this increases the difficulty of its formulation as a medicinal product. By far, the most convenient route of administration of...