The network approach assumes that it is the symptoms themselves that are of primary causal interest. For example, guilt might cause sadness, which causes suicidality and sleep problems; the direction and strength of direct connections between symptoms can be evaluated, as has been done in several ...
Significance: The re- sults of this study show that cocaine dependence is associated with a loss of psychostimulant-induced dopamine release in the striatum, with no change in D1 receptor availability in this brain region. It also puts these changes in neurochemistry into perspective by cor- ...