In particular we will focus on the following questions: (1) What is the clinical and prognostic impact of natural immune response mechanisms (2) What are the escape mechanisms developed by the tumor which limit the efficiency of the immune system and/or immunotherapy (3) What is the impact ...
Importance of PPPM approach in improvement of the overall management of COVID-19-caused neurological problems COVID-19-caused neurological problems are a gradually developing process since CoV-2 infection. Studies on the routes for CoV-2 entry to the central nervous system (CNS), the cellular ma...
T cells learn to discriminate self from non-self during development in the thymus, and while their primary function as naive T cells is to survey the body for foreign antigen, they maintain a lifelong relationship with the self-immunopeptidome [1], [2]. Interestingly, the range of affinities...
Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of survivin studies in the cancer field. Many studies have provided intriguing insight into ...
Evolution leaves an imprint in species through genetic change. At the molecular level, evolutionary changes can be explored by studying ratios of nucleotide substitutions. The interplay among molecular evolution, derived phenotypes, and ecological ranges
Importance of PPPM approach in improvement of the overall management of COVID‑19‑caused neurological problems the host and highlight if SARS-CoV-2 would replicate in cells of human BBB in the presence of an accompanied neu- rodegenerative condition and the underlying molecular or...
2. Biosynthesis Is a Solely Green and Sustainable Technology for AgNPs Synthesis Metal nanoparticles are well known for their unique physical, chemical, and biological properties, which depend on their size, shape, and surface charge [12,13]. The morphology and dispersity of metal nanoparticles depe...
[1,4–6]. Overall, the primary drawback of these intracellular delivery strategies lies in their need of an endocytic pathway to overcome the cell membrane barrier, rendering these macromolecular drugs unable to escape from the endosomes, thereby causing their ultimate degradation in the lysosomes ...
The overall balance in the quantity and the quality of mitochondria in a cell is re- ferred to as mitochondrial homeostasis maintenance. Mitochondrial fission/fusion and autophagy-selective degradation (also known as mitophagy) represent two major ap- proaches to balance the number and size of ...
2. Biosynthesis Is a Solely Green and Sustainable Technology for AgNPs Synthesis Metal nanoparticles are well known for their unique physical, chemical, and biological properties, which depend on their size, shape, and surface charge [12,13]. The morphology and dispersity of metal nanoparticles depe...