【EIU咨询•医疗】What is drug lag? The delay between when a drug is available in one country, to when it is available in other countries, with local regulatory approval used as the benchmark. Here The Economist I
Cons of investing in health care Despite boasting some impressive benefits, health care investments also have some potential downsides to consider as well: Regulatory risk: A major headwind for the sector is regulatory risk, which relates to drug pricing and cost control, as well as potential shif...
It is of vital importance in this phase to expose the patient to the attitudes and behaviors that may promote the long-term maintenance of weight loss and prevent its associated consequences with a comprehensive and sustained effort, which involves devising an individualized, appropriate approach to...
The phase III RELATIVITY-047 trial tested first-line treatment with the combination of anti-PD-1 (nivolumab) and an anti-LAG-3 (relatlimab in this case) versus single-agent nivolumab in advanced melanoma patients.18 The trial demonstrated an improved median PFS of 10.1 versus 4.6 months (haz...
Another reason you might want to take melatonin is jet lag. If you jettison around the world, you understand that your body’s clock can get wacky and this comes with a lot of symptoms, the least being insomnia or delayed sleep phase syndrome. Melatonin supplements can be used to get your...
in the prevention of autoimmune reactions [1]. However, the same mechanisms can be exploited by cancer cells to elude immune system attack [2]. Indeed, it is well known that the upregulation of these molecules in immune cells infiltrating the tumor microenvironment (TME) or on cancer cells ...
It took about two hours for Adderall to start working and three hours for Vyvanse, and the effects of each drug lasted for approximately 16 hours. 5,6Another study found similarities in their pharmacokinetics and pharmacodynamics, but there was a lag time of about an hour for d-amphetamine (...
The term nonlinear applies to systems whose components interact in a non-additive way. Nonlinear coupling may lead to an extraordinary range of dynamics, including different classes of abrupt changes, (such as bifurcations), deterministic chaos, nonlinear phase transitions, pacemaker entrainment and rese...
COVID-19 is an emergent disease with many unknown aspects of its pathogenesis, and the main therapeutic approaches [8], consist of immunotherapies and antivi- ral drugs. Notwithstanding, the absence of a single spe- cific antiviral therapy for CoV resides in its novelty since COVID-19 was ...
been proven to be safe in other autoimmune conditions, will not have the same safety profile in MS due to immunopathogenetic differences in these diseases (e.g., daclizumab). Identification of SAEs in clinical trials is difficult highlighting the importance of phase IV studies. Memory B cells ...