Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung cancers and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While the majority of tumours express a neuroendocrine programme (integrating neural and endocrine pro...
The glomerular filtration rate (GFR) is a measure of how well your kidneys are removing waste from your blood, which can be determined using an estimated GFR (eGFR) test. The test gets its name from glomeruli -- the parts of your kidney that filter out waste. ...
What is the purpose OF Glucose Broth and OF Glucose Broth with Oil test? What do these two tests measure? Explain why the use of oil is significant. What is the purpose of OF Glucose Broth and OF Glucose Broth with Oil test? What do these two tests measure. Explain why the ...
The existence of a cancerous lesion can sometimes be detected through the analysis of the altered behaviour of cells that are located substantial distances away from the primary lesion, a phenomenon that is known as the 'field effect'. Partial wave spectroscopy takes advantage of the field effect...
While the recruitment of immune cells to the site of infection is in many cases necessary for viral clearance, the response of airway structural cells to virus and subsequent contributions to virus-induced remodeling phenotypes – in both the absence and presence of chronic airway disease – has ...
Researchers found that many lung cancers had surfaces littered with the excess product of EGFR proteins, so they developed an EGFR inhibitor to suppress these growth factors. It worked, slowing the growth of cancer cells. JAMIE CHAFT And that was pretty revolutionary. And since then, we've ...
Although the pathway of hapten-specific T-cell activation is now well established, several questions need to be addressed: first, what is the nature of the hapten-modified peptides displayed by MHC? Second, how many of these peptides stimulate T-cells?; third, what are the critical protein ...
However, objective response rate (ORR) or progression-free survival (PFS) is limited compared with other molecular-targeted therapies, such as epidermal growth factor receptor (EGFR) inhibitors [13]. Therefore, efforts are being made to develop improved RAS drugs. This review focuses on the ...
the molecular mechanism that regulates host-microbiota homeostasis in normal and ASD states is not known. The analyses needed to address this knowledge gap are challenging to perform in humans and rodents due to the high costs and tedious process of comparing the microbiomes of multiple genetic mod...
Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic disea