Abnormal tumor microenvironment and immune escape in multiple myeloma (MM) are associated with regulatory T cells (Tregs), which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells.
Understanding the interactions between intestinal microbiota, chronic inflammation, cellular stress, and aging is essential to developing therapies aimed at reducing inflammation and slowing age-related diseases in PWH. In this review, we discuss critical knowledge gaps and highlight the therapeutic potentia...
(2) Histopathology can be insightful, and the clinical mycology laboratory needs to collaborate with the pathology department for optimization of care. (3) Rapid diagnosis is important and biomarkers need to carefully replace or reduce spiraling antifungal empiricism. (4) Culture techniques need to...
However, the optimal timing for surgery is difficult to determine, as patients may be asymptomatic for a long period of time, symptoms are usually non-specific and RV size and function are difficult to assess in routine clinical practice. Table 2. Prognostic value of secondary tricuspid ...
Heart failure (HF) is a growing public concern worldwide. Asian countries with large populations carry a much higher risk of HF compared to their Western counterpart. Most patients with HF in these countries are identified during admission for acute decompensated HF (ADHF), thus posing a substant...
Safety and efficacy of injectable and oral maropitant, a selective neurokinin 1 receptor antagonist, in arandomized clinical trial for treatment of vomiting in dogs. J Vet Pharmacol Ther 2008;31:538-543.Benchaoui HA, Cox SR, Schneider RP, et al. The pharmacokinetics of ...
Cardiovascular diseases (CVD) represent to date the leading cause of mortality in both genders in the developed countries. In this context, a strong need for CVD prevention is emerging through lifestyle modification and nutrition. In fact, several studies linked CVD with unhealthy nutrition, alcohol...
transcribing HIV RNA but do not produce infectious virus particles [3,29]. A question then arises of whether the active reservoir is a true reservoir, in other words how would such cells persist for a long time and escape immune-mediated killing. One simple possibility is that no viral ...
manifests as protrusion of the mandible. Both movements are very important for maximum mouth opening and function [12]. A unique aspect of the joint is that both right and left must work in synchrony with partial dislocation. Additionally, the jaw works to maximize intercuspation of the teeth...
What are the effects of drugs on Treg cells in multiple myeloma, and what are the applications of treg cells in therapy? Introduction Multiple myeloma (MM) is the most common form of plasma cell malignancy, accounting for about 1.7% of all malignant tumors [1]. Although the use of a vari...